Solexa’s first product, the Genome Analyzer, launched in 2006 with a retail price of $400,000, and the company was acquired by the American genomics firm Illumina the following year. In 2008, the company published a paper demonstrating their technology’s ability to efficiently sequence whole genomes via short reads. Illumina’s method is commonly known as “sequencing by synthesis.” While the label could technically be applied to other methods, including Sanger’s, which also indirectly assesses sequence by detecting the incorporation of nucleotides complementary to the template strand, it’s most commonly used to refer to Illumina’s chemistry.
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Compact Syntax, Michael Fitzgerald, XML.com. Article introducing