The most promising resource was a post in Russian language by the blogger “axe_chita”, coincidentally published just some days before the start of my efforts. It is a long post that leads the reader into the secrets of QuickBASIC 4 and its compilation model, all in the form of emotional rant. The comments are also insightful, especially this conversation between the author and “firehacker”, which features a side-by-side comparison between a sample BASIC program and its exe form. Was all of this useful? Not at all! Because, spoiler, QuickBASIC 3 compiles programs in a totally different way than its follower! The post links an article from BYTE magazine that confirms this finding.
Plus reactions worked differently: they used T4 DNA polymerase, an enzyme with strong 3’ to 5’ exonuclease activity, meaning it can chew back the end of a DNA strand. In the presence of only one dNTP, T4 DNA polymerase would degrade each fragment from its 3’ end until it reached a nucleotide complementary to that dNTP, at which point the exonuclease activity would be inhibited. This ensured that all fragments in a given plus reaction ended with the same nucleotide.
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March 3, 2026 at 7:32 a.m. PT
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